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Slc32a1tm2(cre)Lowl
Targeted Allele Detail
Nomenclature
Symbol: Slc32a1tm2(cre)Lowl
Name: solute carrier family 32 (GABA vesicular transporter), member 1; targeted mutation 2, Bradford B Lowell
MGI ID: MGI:5141270
Synonyms: vGATiresCre, Vgat-ires-Cre
Gene: Slc32a1  Location: Chr2:158610767-158615748 bp, + strand  Genetic Position: Chr2, 78.72 cM, cytoband H1-3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:174691
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsA targeting vector, constructed from a BAC clone containing the Slc32a1 (Vgat) gene, was utilized to insert an internal ribosomal entry site followed by the cre recombinase sequence into the Slc32a1 locus just downstream of the endogenous stop codon. Cre is expressed from the Slc32a1 gene promoter. (J:174691)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Slc32a1     Summary of all recombinase alleles driven by Slc32a1. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 219972 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Slc32a1 Mutation:  12 strains or lines available
References
Original:  J:174691 Vong L, et al., Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons. Neuron. 2011 Jul 14;71(1):142-54
All:  138 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory