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Slc17a6tm2(cre)Lowl
Targeted Allele Detail
Nomenclature
Symbol: Slc17a6tm2(cre)Lowl
Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6; targeted mutation 2, Bradford B Lowell
MGI ID: MGI:5141269
Synonyms: VGAT-Cre, Vglut2Cre, Vglut2-ires-Cre
Gene: Slc17a6  Location: Chr7:51622006-51671119 bp, + strand  Genetic Position: Chr7, 32.78 cM, cytoband B4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:174691
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsA targeting vector, constructed from a BAC clone containing the Slc17a6 (Vglut2) gene, was utilized to insert an internal ribosomal entry site followed by the cre recombinase sequence into the Slc17a6 locus just downstream of the endogenous stop codon. Cre is expressed from the Slc17a6 gene promoter. (J:174691)
Recombinase
activity
Activity:
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Driver: Slc17a6     Summary of all recombinase alleles driven by Slc17a6. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Slc17a6 Mutation:  42 strains or lines available
References
Original:  J:174691 Vong L, et al., Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons. Neuron. 2011 Jul 14;71(1):142-54
All:  153 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory