Tspyl2^tm1.1Sich
Targeted Allele Detail

Summary

• Symbol: Tspyl2^tm1.1Sich
• Name: TSPY-like 2; targeted mutation 1.1, Siu Yuen Chan
• MGI ID: MGI:5141126
• Synonyms: Tspyl2^-
• Gene: Tspyl2 Location: ChrX:151119848-151125421 bp, - strand Genetic Position: ChrX, 68.46 cM, cytoband F2
• Alliance: Tspyl2^tm1.1Sich page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174549
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon2 and an FRT flanked inverted pgk-neo cassette and loxP site were inserted downstream of exon 5 via homologous recombination. Cre mediated recombination removed exons 2 - 5 and the neo cassette. RT-PCR analysis indicates the absence of all wild-type transcripts in hemizygous male mice; however, a truncated transcript lacking exons 2 - 5 is detected. (J:174549)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tspyl2 Mutation: 8 strains or lines available

References

• Original: J:174549 Tao KP, et al., TSPYL2 is important for G1 checkpoint maintenance upon DNA damage. PLoS One. 2011;6(6):e21602
• All: 3 reference(s)