Tspyl2tm1.1Sich
Targeted Allele Detail
|
Symbol: |
Tspyl2tm1.1Sich |
Name: |
TSPY-like 2; targeted mutation 1.1, Siu Yuen Chan |
MGI ID: |
MGI:5141126 |
Synonyms: |
Tspyl2- |
Gene: |
Tspyl2 Location: ChrX:151119848-151125421 bp, - strand Genetic Position: ChrX, 68.46 cM, cytoband F2
|
Alliance: |
Tspyl2tm1.1Sich page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:174549
|
Parent Cell Line: |
Not Specified (ES Cell)
|
Strain of Origin: |
129S/SvEv
|
|
Allele Type: |
|
Targeted (Null/knockout) |
Mutations: |
|
Insertion, Intragenic deletion
|
|
|
Mutation details: A loxP site was inserted upstream of exon2 and an FRT flanked inverted pgk-neo cassette and loxP site were inserted downstream of exon 5 via homologous recombination. Cre mediated recombination removed exons 2 - 5 and the neo cassette. RT-PCR analysis indicates the absence of all wild-type transcripts in hemizygous male mice; however, a truncated transcript lacking exons 2 - 5 is detected.
(J:174549)
|
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Tspyl2 Mutation: |
6 strains or lines available
|
|
Original: |
J:174549 Tao KP, et al., TSPYL2 is important for G1 checkpoint maintenance upon DNA damage. PLoS One. 2011;6(6):e21602 |
All: |
2 reference(s) |
|