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Mglltm1.1Mwa
Targeted Allele Detail
Nomenclature
Symbol: Mglltm1.1Mwa
Name: monoglyceride lipase; targeted mutation 1.1, Masahiko Watanabe
MGI ID: MGI:5140384
Gene: Mgll  Location: Chr6:88724412-88828360 bp, + strand  Genetic Position: Chr6, 39.51 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:173327
Parent Cell Line:  RENKA (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 3. Cre-mediated recombination removed exons 3 and the neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:173327)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mgll Mutation:  15 strains or lines available
References
Original:  J:173327 Uchigashima M, et al., Molecular and morphological configuration for 2-arachidonoylglycerol-mediated retrograde signaling at mossy cell-granule cell synapses in the dentate gyrus. J Neurosci. 2011 May 25;31(21):7700-14
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory