Mgll^tm1.1Mwa
Targeted Allele Detail

Summary

• Symbol: Mgll^tm1.1Mwa
• Name: monoglyceride lipase; targeted mutation 1.1, Masahiko Watanabe
• MGI ID: MGI:5140384
• Gene: Mgll Location: Chr6:88701397-88805342 bp, + strand Genetic Position: Chr6, 39.51 cM
• Alliance: Mgll^tm1.1Mwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173327
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 3. Cre-mediated recombination removed exons 3 and the neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:173327)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mgll Mutation: 30 strains or lines available

References

• Original: J:173327 Uchigashima M, et al., Molecular and morphological configuration for 2-arachidonoylglycerol-mediated retrograde signaling at mossy cell-granule cell synapses in the dentate gyrus. J Neurosci. 2011 May 25;31(21):7700-14
• All: 9 reference(s)