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Targeted Allele Detail
Symbol: Lrrtm1tm1.1Jaru
Name: leucine rich repeat transmembrane neuronal 1; targeted mutation 1.1, Jun Aruga
MGI ID: MGI:5085889
Gene: Lrrtm1  Location: Chr6:77219672-77234774 bp, + strand  Genetic Position: Chr6, 33.89 cM
Approach toward inanimate objects is altered in Lrrtm1tm1.1Jaru/Lrrtm1tm1.1Jaru mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:174350
Parent Cell Line:  CMTI-2 (ES Cell)
Strain of Origin:  C57BL/6J
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted into exon 2 upstream of the translation initiation site. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. Cre-mediated recombination removed the coding region and neo cassette. (J:174350)
Generation of the Lrrtm1tm1.1Jaru allele
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrrtm1 Mutation:  25 strains or lines available
Original:  J:174350 Takashima N, et al., Impaired cognitive function and altered hippocampal synapse morphology in mice lacking lrrtm1, a gene associated with schizophrenia. PLoS One. 2011;6(7):e22716
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory