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Targeted Allele Detail
Symbol: Lrrtm1tm1.1Jaru
Name: leucine rich repeat transmembrane neuronal 1; targeted mutation 1.1, Jun Aruga
MGI ID: MGI:5085889
Gene: Lrrtm1  Location: Chr6:77242689-77257791 bp, + strand  Genetic Position: Chr6, 33.89 cM
Approach toward inanimate objects is altered in Lrrtm1tm1.1Jaru/Lrrtm1tm1.1Jaru mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:174350
Parent Cell Line:  CMTI-2 (ES Cell)
Strain of Origin:  C57BL/6J
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted into exon 2 upstream of the translation initiation site. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. Cre-mediated recombination removed the coding region and neo cassette. (J:174350)
Generation of the Lrrtm1tm1.1Jaru allele
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrrtm1 Mutation:  3 strains or lines available
Original:  J:174350 Takashima N, et al., Impaired cognitive function and altered hippocampal synapse morphology in mice lacking lrrtm1, a gene associated with schizophrenia. PLoS One. 2011;6(7):e22716
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory