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Targeted Allele Detail
Symbol: Pole4tm1(KOMP)Vlcg
Name: polymerase (DNA-directed), epsilon 4 (p12 subunit); targeted mutation 1, Velocigene
MGI ID: MGI:5085645
Synonyms: Pole4-
Gene: Pole4  Location: Chr6:82618924-82652933 bp, - strand  Genetic Position: Chr6, 35.94 cM, cytoband D1
Mutant Cell Lines:  18012A-C12, 18012A-F2, 18012A-F3, 18012A-G4, 18012A-G8
Germline Transmission:  Earliest citation of germline transmission: J:261973
Parent Cell Line:  VGB6 (ES Cell)
Strain of Origin:  C57BL/6NTac
Project Collection: KOMP-Regeneron
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: ZEN-Ub1
Mutation detailsThe insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 4875bp between positions 82597956-82602830 of Chromosome 6 (Genome Build37). Sequencing of the first exon revealed that the deletion cassette is inserted 94 bp after the start of exon 1. Western blot analysis confirmed loss of protein expression in E13.5 homozygous mutant embryos. (J:136110, J:261973)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 21 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 2 lines available
Carrying any Pole4 Mutation:  4 strains or lines available
Original:  J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory