About   Help   FAQ
Targeted Allele Detail
Symbol: Shank3tm1Yhj
Name: SH3 and multiple ankyrin repeat domains 3; targeted mutation 1, Yong-hui Jiang
MGI ID: MGI:5056336
Synonyms: Shank3e4-9, Shank3/J
Gene: Shank3  Location: Chr15:89499623-89560261 bp, + strand  Genetic Position: Chr15, 44.96 cM
Germline Transmission:  Earliest citation of germline transmission: J:173402
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 4 through 9, which encode the ankyrin repeats, were replaced with a neo cassette. The absence of the 190 kDa but presence of of the 170 kDa and 140 kDa peptides was confirmed by western blot analysis on brian extracts. The a and b isoforms are deleted. (J:173402)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Shank3 Mutation:  39 strains or lines available
Original:  J:173402 Wang X, et al., Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3. Hum Mol Genet. 2011 Aug 1;20(15):3093-108
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.11
The Jackson Laboratory