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Tg(Pdgfra-cre/ERT)467Dbe
Transgene Detail
Nomenclature
Symbol: Tg(Pdgfra-cre/ERT)467Dbe
Name: transgene insertion 467, Dwight E Bergles
MGI ID: MGI:5056164
Synonyms: PDGRaR-CreER
Transgene: Tg(Pdgfra-cre/ERT)467Dbe  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6 x SJL
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsA BAC clone (RP24-148N) was modified by homologous recombination to generate an inducible cre transgene. The cDNA encoding tamoxifen-inducible cre recombinase (cre/ERT) was inserted after the 5' UTR, followed by a rabbit beta-globin poly adenylation sequence. The linearized 150kb construct was injected into pronuclei of 1- or 2-cell stage nuclei from B6SJL mice. Four founders were obtained and crossed to Z/EG reporter animals to assay EGFP expression in offspring. Line 467 displayed the highest cre efficiency and was chosen for further studies. (J:167748)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Pdgfra     Summary of all recombinase alleles driven by Pdgfra. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:167748 Kang SH, et al., NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration. Neuron. 2010 Nov 18;68(4):668-81
All:  52 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory