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Tg(JPH3-GFP,-JPH3*)GXwy
Transgene Detail
Nomenclature
Symbol: Tg(JPH3-GFP,-JPH3*)GXwy
Name: transgene insertion G, X William Yang
MGI ID: MGI:5052365
Synonyms: BAC-HDL2-STOP
Transgene: Tg(JPH3-GFP,-JPH3*)GXwy  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(JPH3-GFP,-JPH3*)GXwy expresses 1 gene
 
Mutation detailsThe human BAC (RP11-33A21) was modified to include a transcriptional stop sequence (GFP followed by a floxed pgk-neo cassette and a polyA signal) before exon 1 and an expanded CTG/CAG track of 120 repeats in exon 2A of JPH3. RT-PCR confirmed that expression of the sense strand CUG repeat is silenced but expression of the antisense CAG repeat is retained. (J:174267)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:174267 Wilburn B, et al., An antisense CAG repeat transcript at JPH3 locus mediates expanded polyglutamine protein toxicity in Huntington's disease-like 2 mice. Neuron. 2011 May 12;70(3):427-40
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/24/2015
MGI 5.21
The Jackson Laboratory