Phb1^tm1.1Bwo
Targeted Allele Detail

Summary

• Symbol: Phb1^tm1.1Bwo
• Name: prohibitin 1; targeted mutation 1.1, Bert W O'Malley
• MGI ID: MGI:5051969
• Synonyms: Phb^fl
• Gene: Phb1 Location: Chr11:95557783-95571599 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
• Alliance: Phb1^tm1.1Bwo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173884
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 4 and 5 were flanked by loxP sites and an FRT flanked neomycin selection cassette was inserted in intron 5 downstream of one of the loxP sites. The neo cassette was subsequently removed by crossing to flp expressing mice. (J:173884)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Phb1 Mutation: 23 strains or lines available

References

• Original: J:173884 He B, et al., Estrogen-regulated prohibitin is required for mouse uterine development and adult function. Endocrinology. 2011 Mar;152(3):1047-56
• All: 6 reference(s)