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Targeted Allele Detail
Symbol: Phbtm1.1Bwo
Name: prohibitin; targeted mutation 1.1, Bert W O'Malley
MGI ID: MGI:5051969
Synonyms: Phbfl
Gene: Phb  Location: Chr11:95666957-95680773 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D
Germline Transmission:  Earliest citation of germline transmission: J:173884
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsExons 4 and 5 were flanked by loxP sites and an FRT flanked neomycin selection cassette was inserted in intron 5 downstream of one of the loxP sites. The neo cassette was subsequently removed by crossing to flp expressing mice. (J:173884)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Phb Mutation:  19 strains or lines available
Original:  J:173884 He B, et al., Estrogen-regulated prohibitin is required for mouse uterine development and adult function. Endocrinology. 2011 Mar;152(3):1047-56
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory