Gpr119^tm1Jleo
Targeted Allele Detail

Summary

• Symbol: Gpr119^tm1Jleo
• Name: G-protein coupled receptor 119; targeted mutation 1, James Leonard
• MGI ID: MGI:5051634
• Gene: Gpr119 Location: ChrX:47756856-47763355 bp, - strand Genetic Position: ChrX, 25.69 cM
• Alliance: Gpr119^tm1Jleo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174048
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced the coding portion of the gene. RT-PCR and immunofluorescence analysis indicated that both mRNA and protein product are absent. (J:174048)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpr119 Mutation: 7 strains or lines available

References

• Original: J:174048 Chu ZL, et al., A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release. Endocrinology. 2007 Jun;148(6):2601-9
• All: 5 reference(s)