Adh5^tm1.1Llli
Targeted Allele Detail

Summary

• Symbol: Adh5^tm1.1Llli
• Name: alcohol dehydrogenase 5 (class III), chi polypeptide; targeted mutation 1.1, Limin Liu
• MGI ID: MGI:5049924
• Synonyms: GSNOR^f
• Gene: Adh5 Location: Chr3:138148854-138161260 bp, + strand Genetic Position: Chr3, 64.26 cM
• Alliance: Adh5^tm1.1Llli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173666
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the neo cassette and left exons 5 and 6 floxed. (J:173666)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adh5 Mutation: 27 strains or lines available

References

• Original: J:173666 Wei W, et al., Targeted deletion of GSNOR in hepatocytes of mice causes nitrosative inactivation of O6-alkylguanine-DNA alkyltransferase and increased sensitivity to genotoxic diethylnitrosamine. Carcinogenesis. 2011 Jul;32(7):973-7
• All: 2 reference(s)