Tg(Pcp2-Prnp)E330Zbz
Transgene Detail
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Symbol: |
Tg(Pcp2-Prnp)E330Zbz |
Name: |
transgene insertion E330, Zurich |
MGI ID: |
MGI:5014494 |
Synonyms: |
Tg(L7-Prnp)E330, Tg(PrPdelta121)E330 |
Transgene: |
Tg(Pcp2-Prnp)E330Zbz Location: unknown
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Alliance: |
Tg(Pcp2-Prnp)E330Zbz page
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Strain of Origin: |
Not Specified
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Pcp2-Prnp)E330Zbz expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
mouse |
Prnp (MGI:97769) |
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Mutation details: Mice bearing this transgene express a truncated mouse prion protein (PRNP) lacking amino acids 32 through 121 under control of the regulatory elements of the Purkinje cell protein 2 (L7) gene. A cDNA encoding the modified PRNP and extending to the EcoR1 site in the 3' UTR was inserted into a cloned mouse genomic DNA segment containing the entire Pcp2 coding region, 4 kb of 5' flanking sequence and 2 kb of 3' flanking sequence. Insertion occurred at the BamH1 site in the fourth (third coding) exon, so the initial translation product has 80 amino acids of PCP2/L7 joined to its amino terminus; these presumably are removed with the PRNP N-terminal leader sequence.
(J:47034, J:82809, J:83952, J:173517)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:83809 Gilbert R, et al., Prolonged dystrophin expression and functional correction of mdx mouse muscle following gene transfer with a helper-dependent (gutted) adenovirus-encoding murine dystrophin. Hum Mol Genet. 2003 Jun 1;12(11):1287-99 |
All: |
5 reference(s) |
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