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Tg(ACTB-Fig4*I41T)705Mm
Transgene Detail
Nomenclature
Symbol: Tg(ACTB-Fig4*I41T)705Mm
Name: transgene insertion 705, Miriam H Meisler
MGI ID: MGI:5014487
Synonyms: FIG4-I41T, Tg705
Transgene: Tg(ACTB-Fig4*I41T)705Mm  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6J x SJL)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(ACTB-Fig4*I41T)705Mm expresses 1 gene
 
Mutation detailsA chicken beta-actin promoter drives expression of a mouse Fig4 cDNA carrying an I41T mutation. This line carries 4 copies of the transgene. Expression levels of Fig4 transcripts were increased 3 fold over non-transgenic controls. (J:173446)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:173446 Lenk GM, et al., Pathogenic Mechanism of the FIG4 Mutation Responsible for Charcot-Marie-Tooth Disease CMT4J. PLoS Genet. 2011 Jun;7(6):e1002104
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/06/2019
MGI 6.14
The Jackson Laboratory