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Tg(Gfap-rtTA,tetO-MAOB,-lacZ)1Jkan
Transgene Detail
Nomenclature
Symbol: Tg(Gfap-rtTA,tetO-MAOB,-lacZ)1Jkan
Name: transgene insertion 1, Julie K Andersen
MGI ID: MGI:5014211
Transgene: Tg(Gfap-rtTA,tetO-MAOB,-lacZ)1Jkan  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence, Reporter, Transactivator)
Inducer:    doxycycline
Mutation:    Insertion
 
Tg(Gfap-rtTA,tetO-MAOB,-lacZ)1Jkan expresses 1 gene
 
Mutation detailsThis transgene consists of 2 co-injected constructs. One encodes for a reverse tetracycline responsive transactivator with expression driven by a murine Gfap promoter. The second has a bidirectional tetracycline responsive promoter that drives expression of a lacZ reporter and a human MOAB cDNA. Several founders were generated and the line with the highest level of expression was used for analyses. Line 1 was generated. (J:132679)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:132679 Mallajosyula JK, et al., MAO-B Elevation in Mouse Brain Astrocytes Results in Parkinson's Pathology. PLoS One. 2008;3(2):e1616
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory