About   Help   FAQ
Tg(Klk8-tTA)SMmay
Transgene Detail
Nomenclature
Symbol: Tg(Klk8-tTA)SMmay
Name: transgene insertion S, Mark Mayford
MGI ID: MGI:5014077
Synonyms: Neuropsin-htTa, Nop-tTA, Prss19-tTA1, Prss19-tTA line 1, TgEC-tTA, tTA-EC
Transgene: Tg(Klk8-tTA)SMmay  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA)F2
Project Collection: Neuroscience Blueprint cre
Transgene
description
Transgene Type:    Transgenic (Transactivator)
Mutation:    Insertion
 
Mutation detailsAn ~120 kb mouse bacterial artificial chromosome (BAC) containing the entire mouse kallikrein related-peptidase 8 (Klk8; also called Prss19 or neuropsin) locus, and ~50 kb of upstream and ~70 kb of downstream sequences, was modified by targeting a human codon-optimized tetracycline-regulated transactivator gene (tTA or htTA or "Tet-Off") into the first exon upstream of the Prss19 translation initiation site. The resulting modified BAC was microinjected into (C57BL/6;DBA)F2 embryos. Founder mice were bred to C57BL/6J inbred mice to establish founder line S. (J:108340, J:151755)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:151755 NIH Neuroscience Blueprint Cre Driver Network, Cre recombinase-expressing mice generated for the NIH Neuroscience Blueprint Cre Driver Network. MGI Direct Data Submission. 2009;
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/14/2021
MGI 6.17
The Jackson Laboratory