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Abcc10tm1Eah
Targeted Allele Detail
Nomenclature
Symbol: Abcc10tm1Eah
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 10; targeted mutation 1, Elizabeth A Hopper-Borge
MGI ID: MGI:5013608
Gene: Abcc10  Location: Chr17:46303221-46328352 bp, - strand  Genetic Position: Chr17, 22.9 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:172648
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 4 through 6 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on kidney cell lines and spleen extracts. (J:172648)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abcc10 Mutation:  24 strains or lines available
References
Original:  J:172648 Hopper-Borge EA, et al., Contribution of Abcc10 (Mrp7) to In Vivo Paclitaxel Resistance as Assessed in Abcc10-/- Mice. Cancer Res. 2011 May 15;71(10):3649-3657
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory