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Ndrg1str
Spontaneous Allele Detail
Nomenclature
Symbol: Ndrg1str
Name: N-myc downstream regulated gene 1; stretcher
MGI ID: MGI:5009138
Synonyms: str
Gene: Ndrg1  Location: Chr15:66929318-66969640 bp, - strand  Genetic Position: Chr15, 29.3 cM, cytoband D3
Mutation
origin
Strain of Origin:  NOD/ShiLtJWehi
Mutation
description
Allele Type:    Spontaneous
Mutation:    Intragenic deletion
 
Mutation detailsMore than 5 kilobase pairs of DNA encompassing exons 10-14 have been deleted. Northern blot analysis of kidney RNA reveals the presence in mutant mice of a shorter than normal mRNA, at levels similar to those of the normal transcript in wild-typie littermates; the cDNA sequence confirms that the mutant mRNA has exon 9 spliced in-frame to exon 15. Western blot analysis of protein extracts from sciatic nerve with antibodies to full-length NDRG1 reveals an intense 43-kDa band in wild-type and a very faint band of 32 kDa in mutant sciatic nerve. (J:172770, J:198695)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ndrg1 Mutation:  20 strains or lines available
Notes
The mutant phenotype was observed during production of the NOD.B6-Slc9a1b/Gem (Chr 4; J:60311) congenic strain. Fine-mapping analysis employing simple sequence length polymorphisms (SSLPs) differentiating NOD, C57BL/6 and DBA/2 (the second parental strain in the mapping cross) demonstrated that the mutation had occurred in a segment of Chr 15 derived from NOD. (J:198695)
References
Original:  J:198695 Chandler D, et al., The stretcher spontaneous neurodegenerative mutation models Charcot-Marie-Tooth disease type 4D [v1; ref status: indexed, http://f1000r.es/8c]. F1000Research. 2013;2
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory