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Mcpt8tm1(cre)Lky
Targeted Allele Detail
Nomenclature
Symbol: Mcpt8tm1(cre)Lky
Name: mast cell protease 8; targeted mutation 1, Richard M Locksley
MGI ID: MGI:5007937
Synonyms: Basoph8, Mcpt8tm1(cre)Lksy
Gene: Mcpt8  Location: Chr14:56319623-56322730 bp, - strand  Genetic Position: Chr14, 28.19 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:172122
Parent Cell Line:  PC3 (ES Cell)
Strain of Origin:  129S4/SvJae-Tg(Prm-cre)70Og
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsA 4.8 kb reporter cassette containing YFP, IRES site, humanized cre recombinase, bGH polyA, and a loxP-flanked neo selection marker was inserted at the Mcpt8 start site via homologous recombination in ES cells contain PrmCre (PC3 cells with Tg(Prm-cre)70Og). Upon crossing male chimeras to wild-type females, the loxP-flanked neo was deleted from the male germline by cre recombination, producing the final knock-in allele. (J:172122)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Mcpt8     Summary of all recombinase alleles driven by Mcpt8. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Mcpt8 Mutation:  17 strains or lines available
References
Original:  J:172122 Sullivan BM, et al., Genetic analysis of basophil function in vivo. Nat Immunol. 2011 Jun;12(6):527-35
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory