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Targeted Allele Detail
Symbol: Masp2tm1Wjsc
Name: mannan-binding lectin serine peptidase 2; targeted mutation 1, Wilhelm J Schwaeble
MGI ID: MGI:5007776
Gene: Masp2  Location: Chr4:148602554-148615499 bp, + strand  Genetic Position: Chr4, 78.76 cM, cytoband E1
Masp2tm1Wjsc/Masp2tm1Wjsc mice exhibit reduced myocardial ischemia/reperfusion injury-induced myocardial damage

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:172218
Parent Cell Line:  E14.1a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 11 and 12 were replaced with a neo cassette via homologous recombination. Absence of mRNA and protein expression were confirmed by northern blotting, qRT-PCR, ELISA, and western blotting. (J:172218)
Generation of the Masp2tm1Wjsc allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Masp2 Mutation:  18 strains or lines available
Original:  J:172218 Schwaeble WJ, et al., Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7523-8
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory