About   Help   FAQ
Dhrs3tm1Lex
Targeted Allele Detail
Nomenclature
Symbol: Dhrs3tm1Lex
Name: dehydrogenase/reductase (SDR family) member 3; targeted mutation 1, Lexicon Pharmaceuticals
MGI ID: MGI:5007106
Gene: Dhrs3  Location: Chr4:144619397-144654779 bp, + strand  Genetic Position: Chr4, 78.14 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:171883
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe gene consists of 6 coding exons (7 total exons). Exons 1 and 2 of transcript NCBI accession BC008980 or exon 1 of transcript Ensembl accession ENST00000376223 were/was targeted. Immunohistochemistry confirmed the absence of protein expression in the limb. (J:171883, J:203823)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Dhrs3 Mutation:  16 strains or lines available
Notes
See also, data as provided by Lexicon Genetics, Inc.
References
Original:  J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/10/2022
MGI 6.19
The Jackson Laboratory