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Targeted Allele Detail
Symbol: Adam18tm1Lex
Name: a disintegrin and metallopeptidase domain 18; targeted mutation 1, Lexicon Pharmaceuticals
MGI ID: MGI:5007009
Gene: Adam18  Location: Chr8:24602246-24674755 bp, - strand  Genetic Position: Chr8, 12.82 cM, cytoband A3
Germline Transmission:  Earliest citation of germline transmission: J:171883
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThe Adam18 gene consists of 20 exons, with the start codon located in exon 1 (NCBI accession NM_010084.1). Exons 1 and 2 were targeted by homologous recombination. Disruption of the target gene was confirmed by Southern hybridization analysis. (J:171883)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Adam18 Mutation:  42 strains or lines available
See also, data as provided by Lexicon Genetics, Inc.
Original:  J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory