Tg(Vps54)#Mm
Transgene Detail

Summary

• Symbol: Tg(Vps54)#Mm
• Name: transgene insertion, Miriam Meisler
• MGI ID: MGI:5006720
• Synonyms: BAC 115F6 transgene, Vps54-BAC-tg, Vps54-tg
• Transgene: Tg(Vps54)#Mm Location: unknown
• Alliance: Tg(Vps54)#Mm page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL/J)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Vps54)#Mm expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Vps54 (MGI:2178798)

• Mutation details: This transgene comprises the bacterial artificial chromosome RPCI 24-115F6, which contains the genomic coding region of the mouse Vps54 locus plus 63 kb of upstream and 18 kb of downstream flanking DNA from the C57BL/6J mouse strain. (J:104824)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Transgenic mouse lines were established from four male founder mice, which were not distinguished from one another. In all four lines, the transgene fully rescued the phenotype of mice homozygous for the spontaneous wobbler mutation, (Vps54^wr). (J:104824)

References

• Original: J:104824 Schmitt-John T, et al., Mutation of Vps54 causes motor neuron disease and defective spermiogenesis in the wobbler mouse. Nat Genet. 2005 Nov;37(11):1213-5
• All: 1 reference(s)