About   Help   FAQ
Ikbketm1Dgen
Targeted Allele Detail
Nomenclature
Symbol: Ikbketm1Dgen
Name: inhibitor of kappaB kinase epsilon; targeted mutation 1, Deltagen
MGI ID: MGI:5006718
Gene: Ikbke  Location: Chr1:131254600-131279601 bp, - strand  Genetic Position: Chr1, 56.93 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:171942
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Project Collection: Deltagen
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details904 bp of the coding region was replaced with an IRES-lacZ reporter and neo cassette. The absence of protein expression was confirmed by western blot analysis on liver and white adipose tissue extracts. (J:171942)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ikbke Mutation:  3 strains or lines available
References
Original:  J:171942 Scheja L, et al., Beneficial effects of IKKepsilon-deficiency on body weight and insulin sensitivity are lost in high fat diet-induced obesity in mice. Biochem Biophys Res Commun. 2011 Apr 8;407(2):288-94
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/24/2020
MGI 6.15
The Jackson Laboratory