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Ccn3tm1Hko
Targeted Allele Detail
Nomenclature
Symbol: Ccn3tm1Hko
Name: cellular communication network factor 3; targeted mutation 1, Haruhiko Koseki
MGI ID: MGI:5004902
Synonyms: Ccn3 KO
Gene: Ccn3  Location: Chr15:54609306-54617158 bp, + strand  Genetic Position: Chr15, 21.49 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:172144
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1, 2, and 3 were replaced with a neo cassette. The absence of protein expression was confirmed by immunohistochemistry on aorta. (J:172144)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ccn3 Mutation:  15 strains or lines available
References
Original:  J:172144 Shimoyama T, et al., CCN3 inhibits neointimal hyperplasia through modulation of smooth muscle cell growth and migration. Arterioscler Thromb Vasc Biol. 2010 Apr;30(4):675-82
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/26/2022
MGI 6.21
The Jackson Laboratory