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Gt(ROSA)26Sortm1(gp80,EGFP)Eces
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1(gp80,EGFP)Eces
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Ethel Cesarman
MGI ID: MGI:5004724
Synonyms: ROSA26.vFLIP
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
A representative tumor in the nose of a Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+ Cd19tm1(cre)Cgn/Cd19+ mouse

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:172031
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Mutation detailsA cassette containing (5' to 3') a splice acceptor, floxed neo/STOP cassette, the coding sequence for Kaposi sarcoma herpesvirus FLICE-inhibitory protein (vFLIP/gp80), and an FRT-flanked IRES-EGFP was inserted into the locus. Cre-mediated recombination is required to achieve expression of the viral protein. (J:172031)
Generation of the Gt(ROSA)26Sortm1(gp80,EGFP)Eces allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  510 strains or lines available
References
Original:  J:172031 Ballon G, et al., Kaposi sarcoma herpesvirus (KSHV) vFLIP oncoprotein induces B cell transdifferentiation and tumorigenesis in mice. J Clin Invest. 2011 Mar 1;121(3):1141-53
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/04/2020
MGI 6.14
The Jackson Laboratory