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Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm1(gp80,EGFP)Eces
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Ethel Cesarman
MGI ID: MGI:5004724
Synonyms: ROSA26.vFLIP
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
A representative tumor in the nose of a Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+ Cd19tm1(cre)Cgn/Cd19+ mouse

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:172031
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, Reporter)
Mutation:    Insertion
Mutation detailsA cassette containing (5' to 3') a splice acceptor, floxed neo/STOP cassette, the coding sequence for Kaposi sarcoma herpesvirus FLICE-inhibitory protein (vFLIP/gp80), and an FRT-flanked IRES-EGFP was inserted into the locus. Cre-mediated recombination is required to achieve expression of the viral protein. (J:172031)
Generation of the Gt(ROSA)26Sortm1(gp80,EGFP)Eces allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  510 strains or lines available
Original:  J:172031 Ballon G, et al., Kaposi sarcoma herpesvirus (KSHV) vFLIP oncoprotein induces B cell transdifferentiation and tumorigenesis in mice. J Clin Invest. 2011 Mar 1;121(3):1141-53
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory