Tg(Prnp/IGHG1)588Aag
Transgene Detail

Summary

• Symbol: Tg(Prnp/IGHG1)588Aag
• Name: transgene insertion 588, Adriano Aguzzi
• MGI ID: MGI:5003488
• Synonyms: PrPFcSTOP588, tg588stop, Tg(Prnp-FcSTOP)588Aag, Tg(PrP/FcStop)Zbz line 588
• Transgene: Tg(Prnp/IGHG1)588Aag Location: unknown
• Alliance: Tg(Prnp/IGHG1)588Aag page

Transgene origin

• Strain of Origin: B6;129S7-Prnp^tm1Cwe

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp/IGHG1)588Aag expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Prnp (MGI:97769)

• Mutation details: The transgene encodes a soluble, dimerizing fusion protein comprising the normal mouse prion protein, without the carboxyl terminal GPI attachment signal, joined to the Fc region of the human immunoglobulin heavy chain gamma 1 constant region (Fcgamma). The construct includes ~6 kb of 5' flanking sequence, exon 1, intron 1 and a fused exon 2/3 from the mouse prion protein gene (Prnp). The Fcgamma coding sequence is modified to eliminate the binding sites for the Fcgamma receptor and complement. A loxP-flanked translation termination (STOP) cassette has been inserted upstream of the open reading frame, blocking expression of the fusion protein until the cassette is excised by Cre recombinase. (J:82734)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:82734 Meier P, et al., Soluble dimeric prion protein binds PrP(Sc) in vivo and antagonizes prion disease. Cell. 2003 Apr 4;113(1):49-60
• All: 1 reference(s)