Eps15^{tm2e(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Eps15^{tm2e(KOMP)Wtsi}
• Name: epidermal growth factor receptor pathway substrate 15; targeted mutation 2e, Wellcome Trust Sanger Institute
• MGI ID: MGI:5002922
• Gene: Eps15 Location: Chr4:109137465-109245014 bp, + strand Genetic Position: Chr4, 51.29 cM, cytoband C7
• IMPC: Eps15 gene page

Mutation origin

• Mutant Cell Lines: EPD0053_1_A08, EPD0053_1_B07, EPD0053_1_B09, EPD0053_1_C09, EPD0053_1_E08, EPD0053_1_G07, EPD0053_1_H07, EPD0053_1_H08, EPD0053_1_H09
• Germline Transmission: Unknown
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion Vector: L1L2_gt0
• Mutation details: The L1L2_gt0 cassette was inserted at position 109178803 of Chromosome 4 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. Insertion of this cassette creates a reporter knockout mouse. Cre expression will remove the neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:148605, J:173534)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eps15 Mutation: 66 strains or lines available

References

• Original: J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009
• All: 2 reference(s)