Tg(Myh6-TRPC3*)6.6Jmol
Transgene Detail

Summary

• Symbol: Tg(Myh6-TRPC3*)6.6Jmol
• Name: transgene insertion 6.6, Jeffery Molkentin
• MGI ID: MGI:5002483
• Synonyms: dnTRPC3
• Transgene: Tg(Myh6-TRPC3*)6.6Jmol Location: unknown
• Alliance: Tg(Myh6-TRPC3*)6.6Jmol page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-TRPC3*)6.6Jmol expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TRPC3 (7222)

  Trpc3

  (MGI:109526)

• Mutation details: The dnTRPC3 transgene contains amino acids 1-302 of the human transient receptor potential cation channel, subfamily C, member 3 (TRPC3) under the control of the mouse myosin, heavy polypeptide 6, cardiac muscle, alpha (Myh6) promoter. Line 6.6 was generated. (J:159297)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:159297 Wu X, et al., TRPC channels are necessary mediators of pathologic cardiac hypertrophy. Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):7000-5
• All: 1 reference(s)