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Targeted Allele Detail
Symbol: Col5a3tm1Dgr
Name: collagen, type V, alpha 3; targeted mutation 1, Daniel S Greenspan
MGI ID: MGI:5000519
Gene: Col5a3  Location: Chr9:20770050-20815067 bp, - strand  Genetic Position: Chr9, 7.63 cM
Reduced thickness of the adipocyte-rich hypodermal layer of Col5a3tm1Dgr/Col5a3tm1Dgr females

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:171817
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 1.2 kb genomic fragment including 3 C-propeptide exons was replaced with a neo cassette via homologous recombination. Immunoblot and RT-PCR analysis of E15.5 homozygous embryos confirmed the absence of RNA and protein expression. (J:171817)
Generation of the Col5a3tm1Dgr allele
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col5a3 Mutation:  37 strains or lines available
Original:  J:171817 Huang G, et al., alpha3(V) collagen is critical for glucose homeostasis in mice due to effects in pancreatic islets and peripheral tissues. J Clin Invest. 2011 Feb 1;121(2):769-83
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory