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Targeted Allele Detail
Symbol: Col5a3tm1Dgr
Name: collagen, type V, alpha 3; targeted mutation 1, Daniel S Greenspan
MGI ID: MGI:5000519
Gene: Col5a3  Location: Chr9:20770050-20815067 bp, - strand  Genetic Position: Chr9, 7.63 cM
Reduced thickness of the adipocyte-rich hypodermal layer of Col5a3tm1Dgr/Col5a3tm1Dgr females

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:171817
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 1.2 kb genomic fragment including 3 C-propeptide exons was replaced with a neo cassette via homologous recombination. Immunoblot and RT-PCR analysis of E15.5 homozygous embryos confirmed the absence of RNA and protein expression. (J:171817)
Generation of the Col5a3tm1Dgr allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col5a3 Mutation:  34 strains or lines available
Original:  J:171817 Huang G, et al., alpha3(V) collagen is critical for glucose homeostasis in mice due to effects in pancreatic islets and peripheral tissues. J Clin Invest. 2011 Feb 1;121(2):769-83
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory