Trib1^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Trib1^tm1Aki
• Name: tribbles pseudokinase 1; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:5000311
• Gene: Trib1 Location: Chr15:59520503-59528948 bp, + strand Genetic Position: Chr15, 25.41 cM
• Alliance: Trib1^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126085
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The second coding exon was replaced with a neo cassette. The absence of transcript expression was confirmed by northern blot analysis on macrophage extracts. (J:126085)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trib1 Mutation: 23 strains or lines available

References

• Original: J:126085 Yamamoto M, et al., Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency. J Exp Med. 2007 Sep 3;204(9):2233-9
• All: 8 reference(s)