Tg(YAC18)212Hay
Transgene Detail

Summary

• Symbol: Tg(YAC18)212Hay
• Name: transgene insertion 212, Michael Hayden
• MGI ID: MGI:5000283
• Synonyms: YAC18 (line 212)
• Transgene: Tg(YAC18)212Hay Location: unknown
• Alliance: Tg(YAC18)212Hay page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A YAC containing a full-length human huntingtin gene under the control of the endogenous human HDH promoter was modified with a 18 CAG repeat expansion. The resulting construct (YAC18) was used to generate transgenic mice. Line 212 was generated. (J:84453)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:171134 Song W, et al., Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity. Nat Med. 2011 Mar;17(3):377-82
• All: 3 reference(s)