Gt(ROSA)26Sor^{tm2(MYC/ERT)Hsc}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(MYC/ERT)Hsc}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Hubert Schorle
• MGI ID: MGI:5000147
• Synonyms: ROSAMER
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(MYC/ERT)Hsc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89756
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Inducible, Inserted expressed sequence)
• Inducer: tamoxifen
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm2(MYC/ERT)Hsc} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MYC (4609)

  Bmyc	(MGI:88184)
  Myc	(MGI:97250)

• Mutation details: The knocked-in segment contains a splice acceptor, floxed neo STOP cassette, human MYC fused with ERT (a modified estrogen receptor rendered insensitive to estrogen but responsive to tamoxifen), and a polyadenylation sequence. (J:89756)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1041 strains or lines available

References

• Original: J:89756 Jager R, et al., Cell type-specific conditional regulation of the c-myc proto-oncogene by combining Cre/loxP recombination and tamoxifen-mediated activation. Genesis. 2004 Mar;38(3):145-50
• All: 1 reference(s)