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Nek7tm1Mot
Targeted Allele Detail
Nomenclature
Symbol: Nek7tm1Mot
Name: NIMA (never in mitosis gene a)-related expressed kinase 7; targeted mutation 1, Benny Motro
MGI ID: MGI:4999797
Gene: Nek7  Location: Chr1:138483837-138619757 bp, - strand  Genetic Position: Chr1, 60.82 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:168166
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsMost of exons 3 and 4 of the gene is replaced with b-galactosidase (b-gal)-Neo resistance cassette, which deletes 1630 bp and insert premature termination of Nek7 coding at amino-acid 75 but leaving intact the splice acceptor site of exon 3 and the splice donor site of exon 4. Western blot confirmed absence of protein product in cultured MEF. This is a null allele. (J:168166)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nek7 Mutation:  11 strains or lines available
References
Original:  J:168166 Salem H, et al., Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy. Oncogene. 2010 Jul 15;29(28):4046-57
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory