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Targeted Allele Detail
Symbol: Guca1atm1.1Hunt
Name: guanylate cyclase activator 1a (retina); targeted mutation 1.1, David M Hunt
MGI ID: MGI:4999776
Synonyms: Guca1aCOD3
Gene: Guca1a  Location: Chr17:47394560-47400584 bp, - strand  Genetic Position: Chr17, 23.07 cM, cytoband D
Progressive loss of cone photoreceptors in Guca1atm1.1Hunt/Guca1a+ and Guca1atm1.1Hunt/Guca1atm1.1Hunt mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:171667
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Humanized sequence)
Mutation:    Insertion
Mutation detailsExon 4 was replaced with a floxed neo cassette and a modified exon 4, which contained an A to G transition that results in the amino acid substitution of glycine for glutamic acid at position 155 (E155G), mimicking a mutation found in some cone dystrophy 3 (COD3) patients. Cre-mediated recombination removed the neo cassette. (J:171667)
Generation of the Guca1atm1.1Hunt allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Guca1a Mutation:  7 strains or lines available
Original:  J:171667 Buch PK, et al., Dominant cone-rod dystrophy: a mouse model generated by gene targeting of the GCAP1/Guca1a gene. PLoS One. 2011;6(3):e18089
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory