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Targeted Allele Detail
Symbol: Ccl2tm1.1Pame
Name: chemokine (C-C motif) ligand 2; targeted mutation 1.1 Eric G Pamer
MGI ID: MGI:4950271
Synonyms: Ccl2-RFPflox, Mcp1f
Gene: Ccl2  Location: Chr11:82035577-82037452 bp, + strand  Genetic Position: Chr11, 49.82 cM, cytoband C-E1
Germline Transmission:  Earliest citation of germline transmission: J:171379
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  B6(Cg)-Tyrc-2J
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 2. Exon 3 was replaced with a modified exon 3 with an HA-2A cleavable mCherry and 3' loxP site. A floxed neo cassette used for selection purposes was removed by cre-mediated recombination. (J:171379)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ccl2 Mutation:  7 strains or lines available
Original:  J:171379 Shi C, et al., Bone Marrow Mesenchymal Stem and Progenitor Cells Induce Monocyte Emigration in Response to Circulating Toll-like Receptor Ligands. Immunity. 2011 Apr 22;34(4):590-601
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory