Ccl2^tm1.1Pame
Targeted Allele Detail

Summary

• Symbol: Ccl2^tm1.1Pame
• Name: C-C motif chemokine ligand 2; targeted mutation 1.1 Eric G Pamer
• MGI ID: MGI:4950271
• Synonyms: Ccl2-RFP^flox, Mcp1^f
• Gene: Ccl2 Location: Chr11:81926403-81928278 bp, + strand Genetic Position: Chr11, 49.82 cM, cytoband C-E1
• Alliance: Ccl2^tm1.1Pame page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171379
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. Exon 3 was replaced with a modified exon 3 with an HA-2A cleavable mCherry and 3' loxP site. A floxed neo cassette used for selection purposes was removed by cre-mediated recombination. (J:171379)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ccl2 Mutation: 25 strains or lines available

References

• Original: J:171379 Shi C, et al., Bone Marrow Mesenchymal Stem and Progenitor Cells Induce Monocyte Emigration in Response to Circulating Toll-like Receptor Ligands. Immunity. 2011 Apr 22;34(4):590-601
• All: 29 reference(s)