Cav2^tm1(KOMP)Mbp
Targeted Allele Detail

Summary

• Symbol: Cav2^tm1(KOMP)Mbp
• Name: caveolin 2; targeted mutation 1, Mouse Biology Program, UC Davis
• MGI ID: MGI:4950154
• Gene: Cav2 Location: Chr6:17281184-17289114 bp, + strand Genetic Position: Chr6, 7.72 cM, cytoband A2
• Alliance: Cav2^tm1(KOMP)Mbp page
• IMPC: Cav2 gene page

Mutation origin

• Mutant Cell Line: DEPD00554_4_D06
• Germline Transmission: Earliest citation of germline transmission: J:217189
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 5261 starting at position 17281880 and ending at position 17287141 of Chromosome 6 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157064, J:217189)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 1 line available
• Carrying any Cav2 Mutation: 18 strains or lines available

References

• Original: J:157064 University of California, Davis, Alleles produced for the KOMP project by the University of California, Davis. MGI Direct Data Submission. 2010
• All: 5 reference(s)