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Ush1gtm1.2Ugds
Targeted Allele Detail
Nomenclature
Symbol: Ush1gtm1.2Ugds
Name: Usher syndrome 1G; targeted mutation 1.2, Unite de Genetique des Deficits Sensoriels
MGI ID: MGI:4950014
Synonyms: Ush1g-
Gene: Ush1g  Location: Chr11:115315192-115322041 bp, - strand  Genetic Position: Chr11, 80.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:171218
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S1/SvImJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 2 and a loxP site and FRT flanked neo cassette were inserted downstream of exon 2 via homologous recombination. Flp mediated recombination removed the neo cassette leaving and cre mediated recombination removed exon 2. (J:171218)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ush1g Mutation:  11 strains or lines available
References
Original:  J:171218 Caberlotto E, et al., Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5825-30
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory