Mecp2tm1Vnar
Targeted Allele Detail
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Symbol: |
Mecp2tm1Vnar |
Name: |
methyl CpG binding protein 2; targeted mutation 1, Vinodh Narayanan |
MGI ID: |
MGI:4949848 |
Synonyms: |
Mecp2*a140v |
Gene: |
Mecp2 Location: ChrX:73070198-73129296 bp, - strand Genetic Position: ChrX, 37.63 cM
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Alliance: |
Mecp2tm1Vnar page
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Frontal cortex and olfactory bulbs of Mecp2tm1Vnar/Y mice exhibit an increase in cell density
Show the 4 phenotype image(s) involving this allele.
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Allele Type: |
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Targeted (Humanized sequence) |
Mutations: |
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Insertion, Single point mutation
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Mutation details: A targeting construct was designed to insert a loxP site followed by a frt-flanked neomycin (neo) resistance cassette upstream of exon 3 of the methyl CpG binding protein 2 (Mecp2) gene. A second loxP site was inserted in the 3' untranslated region of exon 4. A point mutation was introduced in exon 4, resulting in a missense mutation, A140V, commonly found in humans carrying Rett Syndrome (RTT) X-linked mental retardation. Normal transcript stability was confirmed by quantitative qRT-PCR.
(J:171410)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Mecp2 Mutation: |
38 strains or lines available
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Original: |
J:171410 Jentarra GM, et al., Abnormalities of cell packing density and dendritic complexity in the MeCP2 A140V mouse model of Rett syndrome/X-linked mental retardation. BMC Neurosci. 2010;11:19 |
All: |
1 reference(s) |
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