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Map2k7tm1.1Twad
Targeted Allele Detail
Nomenclature
Symbol: Map2k7tm1.1Twad
Name: mitogen-activated protein kinase kinase 7; targeted mutation 1.1, Teiji Wada
MGI ID: MGI:4948950
Synonyms: Map2k7fl, Mkk7fl
Gene: Map2k7  Location: Chr8:4238740-4251423 bp, + strand  Genetic Position: Chr8, 1.99 cM, cytoband A1.1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:170904
Parent Cell Line:  A9 (ES Cell)
Strain of Origin:  (C57BL/6 x 129P2/OlaHsd)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 3. An FRT- and loxP-flanked neo cassette was inserted downstream of exon 10. Flp-mediated recombination removed the neo cassette, leaving exons 3 through 10 floxed. (J:170904)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Map2k7 Mutation:  5 strains or lines available
References
Original:  J:170904 Schramek D, et al., The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression. Nat Genet. 2011 Mar;43(3):212-9
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory