Parp3^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Parp3^tm1.1Ics
• Name: poly (ADP-ribose) polymerase family, member 3; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:4948939
• Synonyms: Parp3flox
• Gene: Parp3 Location: Chr9:106347521-106354148 bp, - strand Genetic Position: Chr9, 57.58 cM
• Alliance: Parp3^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170941
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT- and loxP flanked neo cassette was inserted upstream of exon 3. A loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the neo cassette, leaving exons 3 through 5 floxed. (J:170941)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Parp3 Mutation: 34 strains or lines available

References

• Original: J:170941 Boehler C, et al., Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2783-8
• All: 2 reference(s)