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Targeted Allele Detail
Symbol: Egln1tm1.2Brei
Name: egl-9 family hypoxia-inducible factor 1; targeted mutation 1.2, George Breier
MGI ID: MGI:4948912
Gene: Egln1  Location: Chr8:124908587-124949254 bp, - strand  Genetic Position: Chr8, 72.86 cM
Germline Transmission:  Earliest citation of germline transmission: J:170943
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsCre-mediated recombination removed exons 2 and 3. The absence of protein expression was confirmed by western blot analysis on E14.5 heart extracts. (J:170943)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Egln1 Mutation:  12 strains or lines available
Original:  J:170943 Holscher M, et al., Cardiomyocyte-specific Prolyl-4-hydroxylase Domain 2 Knock Out Protects from Acute Myocardial Ischemic Injury. J Biol Chem. 2011 Apr 1;286(13):11185-94
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory