Tg(Ttr-Hfe*C294Y)1Nca
Transgene Detail

Summary

• Symbol: Tg(Ttr-Hfe*C294Y)1Nca
• Name: transgene insertion 1, Nancy C Andrews
• MGI ID: MGI:4948233
• Synonyms: Hfe^C294Y
• Transgene: Tg(Ttr-Hfe*C294Y)1Nca Location: unknown
• Alliance: Tg(Ttr-Hfe*C294Y)1Nca page

Transgene origin

• Strain of Origin: C57BL/6NCrl

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ttr-Hfe*C294Y)1Nca expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Hfe (MGI:109191)

• Mutation details: The promoter drives hepatocyte-specific of the mouse cDNA with nucleotide substitutions that results in the amino acid substitution of tyrosine for cysteine at position 294 (C294Y). This mutation correspond to the human C282Y disease-causing mutation. (J:167407)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:167407 Schmidt PJ, et al., Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin. Blood. 2010 Dec 16;116(25):5679-87
• All: 1 reference(s)