Tg(Ttr-Hfe*)1Nca
Transgene Detail

Summary

• Symbol: Tg(Ttr-Hfe*)1Nca
• Name: transgene insertion 1, Nancy C Andrews
• MGI ID: MGI:4948232
• Synonyms: Hfe^deltaCD
• Transgene: Tg(Ttr-Hfe*)1Nca Location: unknown
• Alliance: Tg(Ttr-Hfe*)1Nca page

Transgene origin

• Strain of Origin: C57BL/6NCrl

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ttr-Hfe*)1Nca expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Hfe (MGI:109191)

• Mutation details: The promoter drives hepatocyte-specific of the mouse cDNA lacking the 1020 bp, which code for the final C-terminal 19 amino acids. Line 1 does not contain the myc tag that is present in other lines. (J:167407)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:167407 Schmidt PJ, et al., Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin. Blood. 2010 Dec 16;116(25):5679-87
• All: 1 reference(s)