Col18a1^tm1Pih
Targeted Allele Detail

Summary

• Symbol: Col18a1^tm1Pih
• Name: collagen, type XVIII, alpha 1; targeted mutation 1, Taina Pihlajaniemi
• MGI ID: MGI:4948124
• Synonyms: Col18a1^P1
• Gene: Col18a1 Location: Chr10:76888013-77002351 bp, - strand Genetic Position: Chr10, 39.72 cM, cytoband B5-C1
• Alliance: Col18a1^tm1Pih page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170560
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Not Specified
• Mutation details: Exon 1 was inactivated to form a promoter 1-specific knockout. Immunohistochemistry confirmed the lack of the short isoform protein in kidney samples. (J:170560, J:212252)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col18a1 Mutation: 138 strains or lines available

References

• Original: J:170560 Kinnunen AI, et al., Lack of collagen XVIII long isoforms affects kidney podocytes, whereas the short form is needed in the proximal tubular basement membrane. J Biol Chem. 2011 Mar 11;286(10):7755-64
• All: 6 reference(s)