Xirp2^tm1.1Itl
Targeted Allele Detail

Summary

• Symbol: Xirp2^tm1.1Itl
• Name: xin actin-binding repeat containing 2; targeted mutation 1.1, inGenious Targeting Laboratory
• MGI ID: MGI:4947972
• Synonyms: Xirp2 loxP, Xirp2^tm1.1Igl
• Gene: Xirp2 Location: Chr2:67276343-67356964 bp, + strand Genetic Position: Chr2, 39.31 cM
• Alliance: Xirp2^tm1.1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170869
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exons 4 through 6 and the neo cassette. The absence of full-length transcript expression was confirmed by RT-PCR on cardiac cDNA. However, an in-frame transcript splicing exon 3 to exon 7 was produced. (J:170869)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Xirp2 Mutation: 163 strains or lines available

References

• Original: J:170869 McCalmon SA, et al., Modulation of angiotensin II-mediated cardiac remodeling by the MEF2A target gene Xirp2. Circ Res. 2010 Mar 19;106(5):952-60
• All: 1 reference(s)