Trp53^tm5.1Rivm
Targeted Allele Detail

Summary

• Symbol: Trp53^tm5.1Rivm
• Name: transformation related protein 53; targeted mutation 5.1, National Institute of Public Health and Environmental Protection (RIVM)
• MGI ID: MGI:4947933
• Synonyms: Trp53^stop5
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C

Mutation origin

• Germline Transmission: Unknown
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A loxP site flanked puromycin resistance gene cassette was inserted into intron 1. Glutamic acid codon 5 (GAG) in exon 2 was changed to a stop codon (TAG) (p.E5*). Cre-mediated recombination removed the puro cassette. (J:170769)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 249 strains or lines available

Notes

This allele was originally generated in D3 cells containing Trp53^tm1Tyj.

References

• Original: J:170769 Melis JP, et al., Genotoxic exposure: novel cause of selection for a functional DeltaN-p53 isoform. Oncogene. 2011 Apr 14;30(15):1764-72
• All: 1 reference(s)