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Targeted Allele Detail
Symbol: Rapgef3tm1Utak
Name: Rap guanine nucleotide exchange factor (GEF) 3; targeted mutation 1, Utako Yokoyama
MGI ID: MGI:4947366
Synonyms: Epac1-
Gene: Rapgef3  Location: Chr15:97744770-97767972 bp, - strand  Genetic Position: Chr15, 53.74 cM
Germline Transmission:  Earliest citation of germline transmission: J:170436
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsPart of exon 1 and exon 2 were replaced with a floxed neo cassette. The absence of transcript expression was confirmed by northern blot analysis on brain extracts. (J:170436)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rapgef3 Mutation:  18 strains or lines available
Original:  J:170436 Suzuki S, et al., Differential roles of Epac in regulating cell death in neuronal and myocardial cells. J Biol Chem. 2010 Jul 30;285(31):24248-59
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
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