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Juptm1.2Glr
Targeted Allele Detail
Nomenclature
Symbol: Juptm1.2Glr
Name: junction plakoglobin; targeted mutation 1.2, Glenn L Radice
MGI ID: MGI:4947240
Gene: Jup  Location: Chr11:100368958-100397763 bp, - strand  Genetic Position: Chr11, 63.47 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:170618
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 1, and a loxP site and an FRT-flanked neo cassette were introduced into intron 1 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exon 1 floxed. Cre mediated recombination removed exon 1. Western blot analysis of E12.5 homozygous embryos confirmed the absence of protein expression. (J:170618)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Jup Mutation:  139 strains or lines available
References
Original:  J:170618 Li J, et al., Cardiac tissue-restricted deletion of plakoglobin results in progressive cardiomyopathy and activation of {beta}-catenin signaling. Mol Cell Biol. 2011 Mar;31(6):1134-44
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory