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Derl2tm1.1Hpl
Targeted Allele Detail
Nomenclature
Symbol: Derl2tm1.1Hpl
Name: Der1-like domain family, member 2; targeted mutation 1.1, Hidde Ploegh
MGI ID: MGI:4947125
Gene: Derl2  Location: Chr11:71007440-71019841 bp, - strand  Genetic Position: Chr11, 43.21 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:170650
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 4. An additional loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the neo cassette. (J:170650)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Derl2 Mutation:  14 strains or lines available
References
Original:  J:170650 Dougan SK, et al., Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes. Mol Cell Biol. 2011 Mar;31(6):1145-59
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory